Scientific American Mind: Single Neuron = Speaks

From: Subject: Scientific American Mind: Single Neuron Speaks Date: Sat, 24 Sep 2005 18:29:12 +0100 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C5C135.DCA84590" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2180 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C5C135.DCA84590 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciammind.com/article.cfm?articleID=0005C3B9-577D-132F-949983414B7F0000 Scientific American Mind: Single Neuron = Speaks

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October=20 2005 issue

Single Neuron=20 Speaks

By Nicole Garbarini


	Image: ISABELLE = CARDINAL=20
	=20

A lone neuron in one of the = brain's key=20 memory centers may be able to distinguish a specific person = or=20 place, negating a long-standing tenet that a group of = neurons is=20 needed to encode any memory.=20

The single-neuron hypothesis comes from a recent study of = epilepsy patients. A team led by researchers at the = California=20 Institute of Technology and the University of California at = Los=20 Angeles implanted small electrodes in the epileptics' brains = to=20 monitor seizure activity. The patients volunteered to watch = a rapid=20 slide show of random images, including photographs of famous = landmarks, politicians and celebrities. The researchers = found that=20 single cells responded to single images, by sorting neural = activity=20 based on the cells' unique timing and response = characteristics.=20

One patient had a neuron that responded to a photograph = of=20 actress Halle Berry but not to images of other actresses. = The same=20 neuron fired when the patient was shown line drawings of the = actress=20 or her name typed on a screen but not other drawings or = names. A=20 single neuron in another patient responded to photographs = and words=20 denoting the Sydney Opera House but not other landmarks.=20

The experiments advance work the group started two years = ago that=20 prompted media discussion of a Bill Clinton gene. Although = the=20 single-concept neuron theory dates back to the 1960s, it had = been=20 dismissed by scientists. Itzhak Fried, one of the current=20 investigators, suggests that one-to-one correlations may be = key to=20 efficient memory storage. It is possible, however, that = neurons not=20 monitored during the procedure were responding to the people = or=20 places presented. Conversely, some neurons fired when two = different=20 images were presented. Co-investigator Rodrigo Quian Quiroga = suggests this might occur if we "associate one particular = person=20 with one particular object and we want to store this = association in=20 long-term memory."







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		Brain's Own Pain Relievers At Work = in Placebo=20 Effect, Study Suggests

		Brain Region Tied to Regret=20 Identified

		Mindful of Symbols

		Monkeys Get Intermediate Grade on = Mirror=20 Test

		Reaching in the Dark



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