From: Subject: =?iso-8859-1?Q?Scientific_American_Mind:_One_Person=2C_One_Neuron=3F_--_N?= =?iso-8859-1?Q?erve_cells_devoted_to_recognizing_Halle_Berry_or_Bill_Clin?= =?iso-8859-1?Q?ton=3F_Absurd._That's_what_most_neuroscientists_though?= =?iso-8859-1?Q?t=AD=AD--until_recently?= Date: Mon, 6 Feb 2006 12:03:35 -0000 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_000E_01C62B15.5B38E240" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2180 This is a multi-part message in MIME format. ------=_NextPart_000_000E_01C62B15.5B38E240 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciammind.com/article.cfm?articleID=000DCBCA-CBCF-13DF-8BCF83414B7F0000 Scientific American Mind: One Person, One Neuron? -- = Nerve cells devoted to recognizing Halle Berry or Bill Clinton? Absurd. = That's what most neuroscientists thought=AD=AD--until recently
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February=20 2006 issue
One Person,=20 One Neuron?
Nerve cells devoted to = recognizing Halle=20 Berry or Bill Clinton? Absurd. That's what most = neuroscientists=20 thought­­--until recently
By Katja Gaschler
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Image: SABINA = BERRETTA=20 Translational Neuroscience Laboratory, McLean = Hospital,=20 Harvard Medical School
Two = neurons =20 (yellow-green and red blobs) in the amygdala, a = brain=20 region involved in emotions. =
Think of the=20 hundreds of people you can remember ever having met. Add = those=20 individuals--such as celebrities, politicians and other = famous=20 figures--whose faces you know well only from movies, TV and=20 photographs. Is it possible that each of those individuals, = along=20 with thousands of other objects you can easily recognize = from=20 earlier encounters, could be captured in your memory by its = own=20 personal brain cell?=20

Perhaps. A recent study published in the journal Nature = by=20 scientists at the California Institute of Technology and the = University of California, Los Angeles, suggests that our = brains use=20 far fewer cells to interpret any given image than previously = believed. For instance, researchers discovered a "Bill = Clinton cell"=20 that responds almost exclusively to the former president. = Another=20 neuron fires only when the actor Halle Berry comes into = view.=20

The neuron responded to three different pictures of = Clinton=20 but not of other American presidents.

Exactly how the brain recognizes images has been a matter = of=20 debate. Two wildly divergent theories exist. In one, = millions of=20 neurons work together to create a cohesive picture. In the = extreme=20 version of the other, the brain contains a separate neuron = for each=20 individual object and person. In 1967 Polish = neurophysiologist Jerzy=20 Konorski described his theory of "gnostic neurons"--derived = from=20 gnosis, Greek for "rec­og­nition." According to this = theory,=20 the activity of one or several nerve cells determines = whether=20 someone thinks of his boss, wife or grandmother. Jerome = Lettvin,=20 then a neuroscientist at the Massachusetts Institute of = Technology,=20 thus dubbed the neurons "grandmother cells," and the name = stuck.=20

Many researchers immediately criticized the theory: = Wouldn't such=20 one-to-one congruence take up too much space? Opinions were = still=20 much the same two decades later. "It's very hard to take the = grandmother cell theory seriously," commented neurobiologist = and=20 Nobel Prize laureate David H. Hubel in the 1980s.=20

Back then, it was not even clear how to go about = exploring the=20 entire problem of the neuronal foundations of consciousness. = Using=20 electrodes, neurophysiologists at the time had managed to = trace the=20 activity of individual neurons in the brains of monkeys and = cats.=20 But animal subjects cannot discuss their thoughts with us, = making=20 experiments on consciousness and perception more than a = little=20 difficult. Analogous tests on human beings had not yet been=20 undertaken because of the obvious risks of inserting = electrodes into=20 the brain.=20

Surprise Volunteers
In recent years, however, a = set of=20 human volunteers unexpectedly emerged: patients suffering = from forms=20 of epilepsy that cannot be treated with medication. In the = early=20 1990s a number of patients were slated to undergo brain = surgery to=20 remove the zone in their brain responsible for the onsets of = their=20 seizures. Sometimes techniques such as = electroencephalography and=20 magnetic resonance imaging cannot locate the zone precisely = enough.=20 In such cases, neurosurgeons may implant as many as 10 thin=20 electrodes in the brain. These fine sensors monitor neuronal = activity day and night on a continuous basis until the = seizure-onset=20 zone can be localized with sufficient precision and can then = be=20 removed by the neurosurgeon.=20

Researchers realized that this procedure offered a unique = opportunity to study the activities of individual cells. = This fact=20 led neurosurgeon Itzhak Fried of U.C.L.A., one of the = principal=20 investigators in the current research, to design a study as = early as=20 1992 and then invite otherwise untreatable epileptics to = participate=20 in this basic neural research. The grandmother cell study, = carried=20 out with bioengineer Rodrigo Quian Quiroga of the University = of=20 Leicester in England as chief experimentalist, was rather = simple.=20 Test subjects lay in bed watching while photographs flashed = on a=20 computer screen at one-second intervals. At the same time, = Quian=20 Quiroga monitored the electrical signals coming from the = "attached"=20 neurons.

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