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      <P>Obsessed with reruns of the TV sitcom Friends? Well then you =
probably=20
      have at least one =93Jennifer Aniston cell=94 in your brain, =
suggests research=20
      on the activity patterns of single neurons in memory-linked areas =
of the=20
      brain. The results point to a decades-old and dismissed theory =
tying=20
      single neurons to individual concepts and could help =
neuroscientists=20
      understand the elusive human memory.</P>
      <P>=93For things that you see over and over again, your family, =
your=20
      boyfriend, or celebrities, your brain wires up and fires very =
specifically=20
      to them. These neurons are very, very specific, much more than =
people=20
      think,=94 says Christof Koch at the California Institute of =
Technology in=20
      Pasadena, US, one of the researchers.</P>
      <P>In the 1960s, neuroscientist Jerry Lettvin suggested that =
people have=20
      neurons that respond to a single concept such as, for example, =
their=20
      grandmother. The notion of these hyper-specific neurons, coined=20
      =93grandmother cells=94 was quickly rejected by psychologists as =
laughably=20
      simplistic.</P>
      <P>But Rodrigo Quiroga, at the University of Leicester, UK, who =
led the=20
      new study, and his colleagues have found some very =
grandmother-like cells.=20
      Previous unpublished findings from the team showed tantalising =
results: a=20
      neuron that fired only in response to pictures of former US =
president Bill=20
      Clinton, or another to images of the Beatles. But for such =
=93grandmother=20
      cells=94 to exist, they must invariably respond to the =
=93concept=94 of Bill=20
      Clinton, not just similar pictures.</P>
      <H5>Wired up, fired up</H5>
      <P>To investigate further, the team turned to eight patients =
currently=20
      undergoing treatment for epilepsy. In an attempt to locate the =
brain areas=20
      responsible for their seizures, each patient had around 100 tiny=20
      electrodes implanted in their brain. Many of the wires were placed =
in the=20
      hippocampus - an area of the brain vital to long-term memory =
formation.=20
      </P>
      <P>They first gave each subject a screening test, showing them =
between 71=20
      and 114 images of famous people, places, and even food items. For =
each=20
      subject, the researchers measured the electrical activity or =
=93firing=94 of=20
      the neurons connected to the electrodes. Of the 993 neurons =
sampled, 132=20
      fired to at least one image. </P>
      <P>The team then went back for a testing phase, this time showing=20
      participants three to seven different pictures of the initial 132 =
photo=20
      subjects that hit. For example, one woman saw seven different =
photos of=20
      the Jennifer Aniston alongside 80 other photos of animals, =
buildings or=20
      additional famous people such as Julia Roberts. The neuron almost =
ignored=20
      all other photos, but fired steadily each time Aniston appeared on =

      screen.</P>
      <H5>Conceptual connections</H5>
      <P>The team found similar results with another woman who had a =
neuron for=20
      pictures of Halle Berry, including a drawing of her face and an =
image of=20
      just the words of her name. =93This neuron is responding to the =
concept, the=20
      abstract entity, of Halle Berry,=94 says Quiroga. =93If you show a =
line=20
      drawing or a profile, it=92s the same response. We also showed =
pictures of=20
      her as Catwoman, and you can hardly see her because of the mask. =
But if=20
      you know it is Halle Berry then the neurons still fire.=94 </P>
      <P>Given more time and an exhaustive list of images, the team may =
well=20
      have landed upon other images that spiked the activity of the =
=93Halle=20
      Berry=94 neuron. In one participant, the =93Jen=94 neuron also =
fired in response=20
      to a picture of her former Friends cast-mate, Lisa Kudrow. The =
pattern=20
      suggests that the actresses are tied together in the memory =
associations=20
      of this particular woman, says Charles Connor, a neuroscientist at =
Johns=20
      Hopkins University in Baltimore, US. </P>
      <P>These object-specific neurons may be at the core of how we make =

      memories, say Connor. =93I think that=92s the excitement to these =
results,=94 he=20
      says. =93You are looking at the far end of the transformation from =
metric,=20
      visual shapes to conceptual memory-related information. It is that =

      transformation that underlies our ability to understand the world. =
It=92s=20
      not enough to see something familiar and match it. It=92s the fact =
that you=20
      plug visual information into the rich tapestry of memory that =
brings it to=20
      life.=94</P>
      <P>Journal reference: <I>Nature</I> (vol 435 p =
1102)</P></DIV></DIV>
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