'Oprah neuron' hints = at nature of memory - life - 23 July 2009

Apparently not content with a talk show, a monthly = glossy and,=20 well, mega-stardom, Oprah Winfrey has also penetrated the human brain. = When=20 people see her picture or hear her name, specialised "Oprah neurons" = fire away,=20 new research suggests.

Other public figures shouldn't be jealous. Our heads = are also=20 flush with cells attuned to Jennifer Aniston, Halle Berry, and even = Saddam=20 Hussein.

The study of epileptic patients with electrodes = implanted in=20 their brains isn't an investigation of our celebrity-obsessed culture. = Rather,=20 the research explains how distinct images and sounds of a person can = trigger a=20 general concept of them, says Rodrigo Quian Quiroga, a neuroscientist at the = University of=20 Leicester, UK.

"If I see my mother, I'm not just recognising my = mother," he=20 says. "Many things are happening. I remember the last time I saw her; I = remember=20 what she looks like; I remember that I love her; I remember her = cooking."

Sight and sound

Four years ago, Quian Quiroga's team made headlines = when it=20 reported the existence of neurons=20 that fire at the sight of different pictures Jennifer Aniston, or in = some=20 cases her name spelled out on a computer screen.

To determine if these cells respond to visual cues = only, or to=20 information from other senses as well, Quian Quiroga and his colleagues = added=20 sound to their tests.

"If I said 'Oprah', the way this information is = processed is=20 completely different than if I showed you the name 'Oprah' [as text]," = he=20 says.

The researchers worked with seven patients with epilepsy=20 that was untreatable drugs and who had electrodes implanted in their = brains in=20 order to hunt down the cells responsible for their seizures. Pinpointing = the=20 source of the disturbances allows surgeons to remove the area = responsible and=20 leave healthy parts intact. "If they go through surgery, the outcome is = pretty=20 good. In most cases they get cured without any major deficit," Quian = Quiroga=20 says.

Whoopi too

While doctors waited to pin down these seizures, the = team=20 recorded hundreds of electrical signals from individual neurons in the = medial=20 temporal lobe. This large area includes a structure involved in storing = and=20 retrieving memories, the hippocampus (see an=20 interactive map of the brain).

The researchers showed the patients pictures of = celebrities or=20 their names printed out, or they played a computer pronouncing their = name. They=20 also tested famous locales, such as the Eiffel Tower and the World Trade = Center.

Many neurons =E2=80=93 particularly those in the = hippocampus =E2=80=93 fired to=20 specific concepts, whether of Oprah or a building, and for celebrities = the=20 neurons fired whether the stimulus was delivered through sight or sound. = "It is=20 important we have neurons doing this kind of abstraction, this is how we = store=20 memories," Quian Quiroga says.

Yet "Oprah neuron" might be a misnomer. The same = neuron also=20 fired, albeit much more weakly, to Whoopi Goldberg in one patient. = Similarly,=20 Luke Skywalker neurons also responded to Yoda, and those famous Jennifer = Aniston=20 neurons flashed to her former Friends co-star Lisa Kudrow. Such=20 connections could explain how our brain relates two abstract concepts, = Quian=20 Quiroga says.

Non-celebrity neurons

Hollywood stars and Jedi knights aren't the only = concepts with=20 their own patches of neural real estate, of course. After a few days = working=20 with the patients =E2=80=93 whom Quian Quiroga's team members had never = met before =E2=80=93=20 neurons specific to the researchers also appeared. Rodrigo neurons, you = might=20 call them.

This suggests that these associations form quickly, = but how long=20 do they last?

"We don't know and it's a really interesting = question," Quian=20 Quiroga says. "A patient I saw five years ago doesn't need to remember = all the=20 things about me and maybe there aren't as many neurons encoding me = anymore."=20 Similarly, it's easier to locate neurons for familiar people than less = familiar=20 people.

Though Quian Quiroga focused on brain cells piqued by = sight and=20 sound, he thinks that Oprah neurons and their ilk probably respond to=20 information from other senses =E2=80=93 if it's specific enough.

A colleague of Quian Quiroga's had the same thought. = The=20 scientist had served in the military and he remembered a fellow soldier = who=20 hadn't showered in three years, telling Quian Quiroga: "You could smell = him from=20 a mile away. I'm pretty sure I had neurons devoted to this guy."

Journal reference: Current = Biology=20 (DOI: 10.1016/j.cub.2009.06.060)

If you would like to reuse any content from = New=20 Scientist, either in print or online, please contact=20 the syndication department first for permission. New Scientist = does not=20 own rights to photos, but there are a variety of = licensing=20 options available for use of articles and graphics we own the = copyright=20 to.

Have your say

Why Oprah?

Thu Jul 23 21:36:27 BST 2009 by = Cyrus
http://www.sciencedirect.com/science?_ob=3DArticleURL&= ;_udi=3DB6VRT-4WV0B95-7&_user=3D10&_rdoc=3D1&_fmt=3D&_ori= g=3Dsearch&_sort=3Dd&_docanchor=3D&view=3Dc&_acct=3DC0000= 502

NS,

Why the "Oprah" gene instead of the "Marilyn Monroe" gene? = Marilyn=20 was the first celebrtity named in the original article. Getting=20 kickbacks?

reply report this comment

Why Oprah?

Thu Jul 23 22:11:58 BST 2009 by=20 Sabrina

Because who's Maril... whats-her-name?

reply report this comment=20

view thread

No Way, Really?

Thu Jul 23 23:28:38 BST 2009 by = M

A nice waste of funding. The fact that memory is associative has been = known=20 for decades. Also thank you for wasting my time Ewen.

reply report this comment

No Way, Really?

Fri Jul 24 01:04:44 BST 2009 by = Terry

It has been observed externaly, but relating an external observation = of mind=20 to a physical action within the brain are not the same thing.

By = your=20 logic, research that tests for exceptions to general relativity are a = waste of=20 funding.

Such a fine "faith based" scientist you would = be.

reply report this comment=20

view thread

No Way, Really?

Fri Jul 24 02:21:15 BST 2009 by Rick=20 Burlow

M, your comment is worthless and an obvious troll.

Research = like this=20 is only possible due to relatively recent technological advances such as = functional MRI etc. Or perhaps the research needed to turn MRI into = reality was=20 wasted too, since we already had the X-ray, hmm?

Wake up or get = back=20 under your bridge.

reply report this comment=20

view thread

No Way, Really?

Fri Jul 24 04:35:05 BST 2009 by = Lachy

The funny thing is, you wasted your own time by reading the article. = You=20 could have read the first paragraph and then left, but you then used a = similar=20 amount of time to write your unproductive comment

reply report this comment=20

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All comments should respect the New Scientist House = Rules. If=20 you think a particular comment breaks these rules then please use the = "Report"=20 link in that comment to report it to us.

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Sparking the "Oprah neurons" (Image: Bill Davila / = Rex=20 Features)

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=0A= * =0A= * NOTES:=0A= * 1] results will be rendered into the element with id = "contentEnhancement".=0A= * =0A= * 2] the "rbuniqueid1" is very important as noted = https://sites.google.com/a/zibb.com/documentation/Home/Local-Site-Markup/= RBS-Tags=0A= * under the "Table of RBS Tags and Controlled Values" section.=0A= * =0A= * 3] More detailed notes on = https://sites.google.com/a/zibb.com/documentation/Home/Content-Enhancemen= t=0A= * You may need to contact one of this Zibb guys to grant you/your email = address privileges so that you can view the documentation.=0A= * =0A= * 4] Use something like this for a quick keyword test Zibb keyword test=0A= */=0A= =0A= var keywords =3D "";=0A= =0A= var relatedArticleRequest =3D {=0A= requestId :"main",=0A= queryLanguage :"en",=0A= mode :"DocumentVectors",=0A= filters : {=0A= industry :"All",=0A= bucketType :"Jobs",=0A= domainType :"All",=0A= customFilter :"domain:newscientistjobs.com"=0A= },=0A= hits :3,=0A= sortBy :"Relevancy"=0A= }=0A= =0A= var infuseRequest =3D {=0A= excludeTags: ['h1', 'a', 'script'],=0A= infusionType : "Keyword",=0A= disambiguationEnabled: false,=0A= infuseInstances: 1,=0A= existingLinkBehavior: "ignore",=0A= caseInsensitive: false,=0A= version: 2=0A= }=0A= =0A= var zodContentEnhancementQuery =3D {=0A= relatedRequests : [ relatedArticleRequest ],=0A= infuseRequest : infuseRequest,=0A= semanticsOutput : {=0A= documentVectors :true=0A= }=0A= }=0A= =0A= /* Callback function which renders related jobs HTML. */=0A= function zodDisplayContentEnhancement(zodContentEnhancementResult) {=0A= relatedResponse =3D = zodContentEnhancementResult.relatedResponses['main'];=0A= if (relatedResponse !=3D undefined && relatedResponse !=3D null=0A= && relatedResponse.results !=3D undefined=0A= && relatedResponse.results !=3D null=0A= && relatedResponse.results.length > 0) {=0A= =0A= outputHtml =3D '

Related Jobs

';=0A= outputHtml +=3D '

';=0A= // linked title=0A= outputHtml +=3D ''=0A= + relatedResponse.results[resultIndex].title=0A= + '';=0A= //outputHtml +=3D '' + = relatedResponse.results[resultIndex].body + '';=0A= outputHtml +=3D '

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sUndefinedOrNull(zodContentEnhancementQuery)) {zodContentEnhancementQuery.infuser=3DzodInfuser;} var zodContentEnhancer=3Dnew = ZodContentEnhancer(zodContentEnhancementQuery);function = getZodInfuser(contentEnhancementQuery,instanceVariableName) {if(isUndefinedOrNull(contentEnhancementQuery)||isUndefinedOrNull(content= EnhancementQuery.infuseRequest)) {return null;} else {var infuseRequest=3DcontentEnhancementQuery.infuseRequest;var = zodInfuser=3Dnew = ZodInfuser(instanceVariableName);if(infuseRequest.excludeTags instanceof = Array) {for(var = excludeTagIndex=3D0;excludeTagIndex0&&url.substr(url.length-1,1)!=3D'&') {url+=3D'&';} url+=3D'ets=3D'+randomNumber;var beacon=3Dnew = Image();beacon.src=3Durl;return true;} function ZodContentEnhancer(contentEnhancementQuery) {this.contentEnhancementQuery=3DcontentEnhancementQuery;this.initialize=3D= initialize;this.enhance=3Denhance;this.getZodContentEnhancementScriptUrl=3D= getZodContentEnhancementScriptUrl;this.getZodMetaRbUniqueId1Value=3DgetZo= dMetaRbUniqueId1Value;this.getZodMetaRbPubIdValue=3DgetZodMetaRbPubIdValu= e;if(isUndefinedOrNull(this.contentEnhancementQuery.seo)||this.contentEnh= ancementQuery.seo=3D=3Dfalse) {this.initialize();} this.enhance();function initialize() {if(this.contentEnhancementQuery!=3Dnull) {var scriptUrl=3Dthis.getZodContentEnhancementScriptUrl();var = metaRbUniqueId1Value=3Dthis.getZodMetaRbUniqueId1Value();var = metaRbPubIdValue=3Dthis.getZodMetaRbPubIdValue();if(metaRbUniqueId1Value!= =3Dnull) {scriptUrl+=3D'?dit=3Did&di=3D'+encodeURIComponent(metaRbUniqueId1Value);= } else {scriptUrl+=3D'?dit=3Durl&di=3D'+encodeURIComponent(window.location);} if(metaRbPubIdValue!=3Dnull) {scriptUrl+=3D'&p=3D'+encodeURIComponent(metaRbPubIdValue);} if(!isUndefinedOrNull(this.contentEnhancementQuery.relatedRequests)&&this= .contentEnhancementQuery.relatedRequests instanceof Array) {scriptUrl+=3D'&rc=3D'+this.contentEnhancementQuery.relatedRequests.lengt= h;for(var = relatedRequestIndex=3D0;relatedRequestIndex0) {scriptUrl+=3D'&f'+relatedRequestIndex+'=3D'+relatedRequest.filters.custo= mFilter;}} if(!isUndefinedOrNull(relatedRequest.hits)&&!isNaN(relatedRequest.hits)) {scriptUrl+=3D'&h'+relatedRequestIndex+'=3D'+relatedRequest.hits;} if(!isUndefinedOrNull(relatedRequest.offset)&&!isNaN(relatedRequest.offse= t)) {scriptUrl+=3D'&o'+relatedRequestIndex+'=3D'+relatedRequest.offset;} if(!isUndefinedOrNull(relatedRequest.minimumHits)&&!isNaN(relatedRequest.= minimumHits)) {scriptUrl+=3D'&mh'+relatedRequestIndex+'=3D'+relatedRequest.minimumHits;= } if(!isUndefinedOrNull(relatedRequest.collapse)) {switch(relatedRequest.collapse.mode) {case'Disabled':case'Domain':scriptUrl+=3D'&scm'+relatedRequestIndex+'=3D= '+relatedRequest.collapse.mode;break;}} if(relatedRequest.highlighted) {scriptUrl+=3D'&hi'+relatedRequestIndex+'=3Dtrue';} switch(relatedRequest.sortBy) 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scriptUrl+=3D'&ets=3D'+Math.floor((new = Date()).getTime()/1000)+'.'+Math.floor(Math.random()*10000000);var = scriptElement=3Ddocument.createElement('script');scriptElement.setAttribu= te('language','JavaScript');scriptElement.setAttribute('type','text/javas= cript');scriptElement.setAttribute('src',scriptUrl);var = headElements=3Ddocument.getElementsByTagName('head');if(headElements.leng= th>0) {headElements[0].appendChild(scriptElement);}}} function getZodContentEnhancementScriptUrl() {return getZodWidgetsUriAuthority()+'/ContentEnhancement.aspx';} function getZodMetaRbUniqueId1Value() {var metaElementName=3Dnull;var = metaElements=3Ddocument.getElementsByTagName('meta');for(var = metaIndex=3D0;metaIndex0) {headElements[0].appendChild(scriptElementYahoo);} this.contentEnhancementQuery.infuser.Infuse();}}} function ZodInfuser(myname) {this.Infuse=3DInfuse;this.Disambiguate=3DDisambiguate;this.SetUrlGenerat= or=3DSetUrlGenerator;this.ExcludeTag=3DExcludeTag;this.MouseOver=3DMouseO= ver;this.MouseOut=3DMouseOut;this.DelayedDisambiguate=3DDelayedDisambigua= te;this.FillDescriptions=3DFillDescriptions;this.IterateDOM=3DIterateDOM;= this.InfuseTextNode=3DInfuseTextNode;this.GeneratePopup=3DGeneratePopup;t= his.RemoveOccurancesOfEntityId=3DRemoveOccurancesOfEntityId;this.Name=3Dm= yname;this.URLGenerator=3DDefaultGenerator;this.ExcludedTags=3Dnew = Array("script","iframe","input","textarea","select");this.getJavaScriptBe= aconCall=3DgetJavaScriptBeaconCall;this.popUpBehaviour=3D"Ambiguous";this= .infuseInstances=3D1;this.existingLinkBehaviour=3D"Ignore";this.additiona= lDisambiguationContent=3Dtrue;this.caseInsensitive=3Dtrue;this.infusionTy= pe=3D"Entity";this.rightHardline=3D600;this.topHardline=3D0;this.popUpDel= ay=3D-1;this.popUpTitle=3D"";this.popUpMaxEntries=3D10;this.waitingElemen= tId;this.waitingTimeoutId;this.timeSinceLastUiUpdate;function = ExcludeTag(tagName) {this.ExcludedTags.push(tagName);} function MouseOver(elementId) {if(this.popupDelay>=3D0) 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{tag=3Darguments[1];} if(arguments.length>2) {variantName=3Darguments[2];} return'zodJump(\''+ zodWidgetsUriAuthority+'images/_jump.gif?tag=3D'+tag+"&url=3D"+getZodUrlE= ncoded(this.URLGenerator(entity["entityTypeId"],entity["localId"],entity[= "displayName"],entity["landingPageId"]))+"&gsid=3D"+entity["globalSemanti= cId"]+"&entitytypeid=3D"+entity["entityTypeId"]+ (isUndefinedOrNull(entity["localId"])?"":"&lid=3D"+entity["localId"])+ (isUndefinedOrNull(entity["displayName"])?"":"&title=3D"+getZodUrlEncoded= (entity["displayName"]))+ (isUndefinedOrNull(entity["description"])?"":"&description=3D"+getZodUrlE= ncoded(entity["description"]))+"&intref=3Dinfusion&variantName=3D"+getZod= UrlEncoded(variantName)+"&zodid=3D"+zodClientId+'\')';} function InfuseTextNode(textNode,parentNode) {var str=3DtextNode.nodeValue;for(var j=3D0;j1)= {continue;} var = searchString=3D"/\\b"+zodEntities[j]["variant"].replace("/","\\/")+"\\b/m= ";if(zodEntities[j]["variant"].search(/"/)=3D=3D0) {searchString=3D"/"+zodEntities[j]["variant"].replace("/","\\/").replace(= /^"/,"\"\\b").replace(/\.?"$/,"\\b.?\"")+"/m";} if(this.caseInsensitive) {searchString=3DsearchString+"i";} var offset=3Dstr.search(eval(searchString));if(offset>-1) {var nameEntry=3DzodEntities[j];var = entitySet=3DnameEntry["entities"];var = variantName=3DnameEntry["variant"];var splitStr=3Dnew Array();var = strToSplit=3D" "+str+" = ";splitStr=3DstrToSplit.split("\"");if(splitStr.length%2=3D=3D0&&splitStr= .length>1) {continue;} if(nameEntry["infusedCount"]=3D=3Dundefined) {nameEntry["infusedCount"]=3Dthis.infuseInstances-1;} else {nameEntry["infusedCount"]=3DnameEntry["infusedCount"]-1;} if(nameEntry["infusedCount"]=3D=3D0) {zodEntities.splice(j,1);} var = anchor=3Ddocument.createElement("a");if(entitySet.length=3D=3D1&&this.pop= UpBehaviour.toLowerCase()!=3D"always") {anchor.setAttribute("href",this.URLGenerator(entitySet[0]["entityTypeId"= 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function(M,N,L,K){M.attachEvent("on"+N,L);};}else{return = function(){};}}}(),_simpleRemove:function(){if(window.removeEventListener= ){return = function(M,N,L,K){M.removeEventListener(N,L,(K));};}else{if(window.detach= Event){return function(L,M,K){L.detachEvent("on"+M,K);};}else{return = function(){};}}}()};}();(function(){var = EU=3DYAHOO.util.Event;EU.on=3DEU.addListener;if(EU.isIE){YAHOO.util.Event= .onDOMReady(YAHOO.util.Event._tryPreloadAttach,YAHOO.util.Event,true);var= = n=3Ddocument.createElement("p");EU._dri=3DsetInterval(function(){try{n.do= Scroll("left");clearInterval(EU._dri);EU._dri=3Dnull;EU._ready();n=3Dnull= ;}catch(ex){}},EU.POLL_INTERVAL);}else{if(EU.webkit&&EU.webkit<525){EU._d= ri=3DsetInterval(function(){var = rs=3Ddocument.readyState;if("loaded"=3D=3Drs||"complete"=3D=3Drs){clearIn= terval(EU._dri);EU._dri=3Dnull;EU._ready();}},EU.POLL_INTERVAL);}else{EU.= _simpleAdd(document,"DOMContentLoaded",EU._ready);}}EU._simpleAdd(window,= 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path=3D"http://l.yimg.com/us.js.yimg.com/lib/mus/js/ymwp/";return = path+'mediaplayer'+suffix;};var = playerScriptSrc=3Dwebplayerjs();if(playerScriptSrc&&playerScriptSrc.lengt= h>0){YAHOO.mediaplayer.elPlayerSource=3Ddocument.createElement("script");= YAHOO.mediaplayer.elPlayerSource.type=3D"text/javascript";YAHOO.mediaplay= er.elPlayerSource.src=3DplayerScriptSrc;document.getElementsByTagName("he= ad")[0].appendChild(YAHOO.mediaplayer.elPlayerSource);}};YAHOO.ympyui.uti= l.Event.addListener(window,"load",YAHOO.mediaplayer.loadPlayerScript);YAH= OO.namespace("YAHOO.MediaPlayer");YAHOO.MediaPlayer=3Dfunction(){this.con= troller=3Dnull;};YAHOO.MediaPlayer.onAPIReady=3Dnew = YAHOO.ympyui.util.CustomEvent("onAPIReady",null,false,YAHOO.ympyui.util.C= ustomEvent.FLAT);}} ------=_NextPart_000_015C_01CA0C1E.9927E040--

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